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Principal Investigator: Bernhard Paulweber


Brief description:

The First Department of Internal Medicine at the Paracelsus Medical University is a large clinical institution with 3 subdivisions: Gastroenterology, Endocrinology/Metabolism, and Nephrology. The institution has a high expertise in diagnosis and treatment of metabolic disorders, particularly diabetes, obesity and dyslipidemias. In 1973 a research group has been established at the department. Since that time research has been conducted in the areas of atherosclerosis, lipidology, insulin resistance and type 2 diabetes. In 1999 a large observational cohort study has been initiated by B. Paulweber (Salzburg Atherosclerosis Prevention Project in subjects at high individual risk, SAPHIR study), in which the role of established and emerging risk factors in development and progression of atherosclerotic vascular disease and diabetes is studied in the Austrian population. About 1100 men aged 40- 60years and 650 women 50-70 years have been recruited for this study. From 2006 to 2008 our research group has participated in the DE-PLAN project, from 2007 to 2009 also in the IMAGE-project.

As a clinical institution the First Department of Internal Medicine is part of the Salzburger Landeskliniken (SALK) and as a teaching unit it is associated with the Paracelsus Medical University of Salzburg. Twenty five physicians are working in the 3 subdivisions of the department. The department harbours a clinical research centre with one full time physician, one full time and one half time study coordinator. At the diabetes clinic four physicians, 3 diabetes nurses and 2 dieticians are working.

Our institution has participated in the DE-PLAN project. About 150 subjects with prediabetes have been recruited for the intervention program, which was group based and lasted for 2 years. The results of the program have been presented at the 6th World Congress for Diabetes Prevention 2010 in Dresden. Members of our research group were also actively engaged in developing European guidelines for diabetes prevention in the IMAGE project.


Main tasks attributed:
Our institution will participate in carrying out work package 2. Subjects with prediabetes will be recruited mainly from 3 cohorts, the SAPHIR population (see above), the DE-PLAN cohort (n=150) and the population based cohort study PARACELSUS 10.000 (n=10.000). We are planning to recruit a total number of about 200 subjects with prediabetes for the ePREDICE project. The intervention will be mainly carried out by personnel of our diabetes clinic.


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